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PhosphoSens PDGFRA Protein Kinase Assays, Substrates & Recombinant Enzymes
Also known as: Platelet derived growth factor receptor alpha • PDGFR2 • CD140a • GAS9 • Alpha platelet-derived growth factor receptor • PDGFR-alpha • MGC74795
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PDGFRA at a glance. PDGFRA activity is measured continuously and directly with the PhosphoSens® AQT0661 substrate, or as an endpoint TRF readout with AQT0653, with no antibodies or coupling enzymes.
- Assay formats
- Kinetic (continuous) · Red (TRF endpoint)
- Assay kits
- 200 or 1,000 assays, from $425
- Publications
- 7 peer-reviewed studies
How pricing works:
Select a kit or substrate below, then request a quote. Bundle discounts apply automatically.
Select a kit or substrate below, then request a quote. Bundle discounts apply automatically.
Real-Time PDGFRA Activity Assays
Continuous, real-time fluorescent assays optimized for quantitative PDGFRA activity measurements, IC50 determination, and mechanistic studies.
Assay Format: Continuous kinetic fluorescence (real-time)
PhosphoSens-Kinetic assays directly quantify enzyme activity by continuously monitoring substrate phosphorylation or dephosphorylation in real time, generating a full progress curve in every well.
Learn more about PhosphoSens-Kinetic →Need pricing or availability? Select a kit or substrate to request a quote below.
Kits
PhosphoSens-Kinetic Kinase Activity Kit - AQT0661
Substrate: AQT0661
Ready-to-use assay kits containing substrate and all essential reagents.
Kit Contents
- Optimized PhosphoSens® substrate (AQT0661)
- ATP, DTT, EGTA, Reaction Buffer & Dilution Buffer
Automatically save 10% when bundling 10ug recombinant enzyme with your 1,000 assay kit. View enzymes
Price: $425
Substrate
PhosphoSens Kinase Substrate AQT0661
See every target AQT0661 assays →
Bulk PhosphoSens® substrate for assay development and high-throughput workflows.
Specifications
- Catalog #: AQT0661
- Phospho-acceptor: Tyrosine
- Validated for: 22 kinases
- Formats: PhosphoSens-Kinetic
Automatically save 10% when bundling Reagent Packs with your substrate. View Reagent Packs
Price: $2795
One substrate, many targets
AQT0661 also assays 17 other kinases
Validated with the same PhosphoSens® substrate, so you can run a selectivity panel in one assay format.
Ready to request pricing for PDGFRA?
Select a kit, substrate, or enzyme above. Our team will confirm pricing, availability, and any applicable bundle discounts.
TRF PDGFRA Screening Assays
Robust endpoint TRF assays optimized for high-throughput screening and quantitative PDGFRA activity measurement in plate-based workflows.
Assay Format: Time-resolved fluorescence (TRF, endpoint)
PhosphoSens-Red assays use europium-based time-resolved fluorescence detection to enable robust, plate-based quantification of enzyme activity, making them well suited for high-throughput screening workflows.
Learn more about PhosphoSens-Red →Need pricing or availability? Select a kit or substrate to request a quote below.
Kits
PhosphoSens-Red Kinase Activity Kit - AQT0653
Substrate: AQT0653
Ready-to-use TRF assay kits containing substrate and essential reagents.
Kit Contents
- Optimized PhosphoSens® substrate (AQT0653)
- ATP, DTT, EGTA, Reaction Buffer & Dilution Buffer
- Europium Detection Solution
Automatically save 10% when bundling 10ug recombinant enzyme with your 1,000 assay kit. View enzymes
Price: $455
Substrate
PhosphoSens Kinase Substrate AQT0653
See every target AQT0653 assays →
Bulk substrate for PhosphoSens-Red TRF assays and high-throughput workflows.
Specifications
- Catalog #: AQT0653
- Phospho-acceptor: Tyrosine
- Validated for: 32 kinases
- Formats: PhosphoSens-Red
Automatically save 10% when bundling Reagent Packs with your substrate. View Reagent Packs
Price: $2795
One substrate, many targets
AQT0653 also assays 29 other kinases
Validated with the same PhosphoSens® substrate, so you can run a selectivity panel in one assay format.
Ready to request pricing for PDGFRA?
Select a kit, substrate, or enzyme above. Our team will confirm pricing, availability, and any applicable bundle discounts.
No recombinant enzymes are currently available for PDGFRA.
Published research on kinases assayed with AQT0661
Studies on other targets that use the same PhosphoSens® substrate as this assay.
Toward Fully Autonomous Closed-Loop Molecular Discovery: A Case Study on JAK Targets
IBM Research, Arctoris et al.
A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2
Hillebrand L, Wang G, Rasch A, … Gehringer M
PhosphoSens assays (± preincubation) used to evaluate covalent JAK3/MK2 inhibitors
Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations
Tangpeerachaikul A, Mente S, Magrino J, … Pelish HE
NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations
Drilon A, Horan JC, Tangpeerachaikul A, … Lin JJ
Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies
Sartini S, Coviello V, Bruno A, … La Motta C
Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F
Ma L, Clayton JR, Walgren RA, … Burkholder TP
Data & Resources
Explore data and documents to support your kinase and phosphatase experiments. Download sample data, protocols and other resources to see how our assays perform and to help you get started in your own lab. All validation data generated using PhosphoSens® assays under recommended conditions.
Sample Report: AQT0734 - EGFR Assay Validation Report
Each validation report provides experimental conditions and data showing:
- Enzyme titration and linearity
- Sensor peptide substrate titration and Km determination
- ATP titration and Km determination
- DMSO titration and assay tolerance
- Inhibitor titration and IC50 determination
Protocol
Inhibitor IC50 Protocol
See how the PhosphoSens-Kinetic Assay can be used to find the IC50 of a kinase inhibitor.
Download Protocol →Webinar
Webinar: Continuous Assay Validation
Discover how continuous assay formats power deep understanding of kinase function. See how PhosphoSens® assays guide inhibitor profiling, selectivity assessment, and mechanistic characterization.
Watch the Webinar →Service
KinSight™ PDGFRA Profiling
Need broader selectivity data? KinSight profiling runs your compounds across our full kinase panel under identical PhosphoSens conditions.
Learn about KinSight →Stay Informed
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