STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
EGFR/HER2 exon 20 mutants
Tyrosine kinase
Covalent inhibitor kineticsInhibitor discovery & SARSelectivity & kinome profilingMechanism & structural biology
PhosphoSens
