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NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations

Lin JJ, Horan JC, Tangpeerachaikul A, … Drilon A · Cancer Discov 2024 · Cancer Discov 14(12):2367-2386

Multiple (ALK & ALK mutants; TRKA, TRKB, TRKC) Multiple kinases Inhibitor discovery & SARSelectivity & kinome profiling PhosphoSens

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