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Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants

Capener JL, Vasta JD, Katis VL, … Bashore FM · Front Chem Biol 2024 · Front Chem Biol 3

SYK and SYK mutants Tyrosine kinase Inhibitor discovery & SAR PhosphoSens

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More publications on SYK

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures

Bradshaw WJ, Harris G, Gileadi O, Katis VL · Structure 2024

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms

Antenucci L, Hytönen VP, Ylänne J · J Biol Chem 2018

The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation

Paris D, Ait-Ghezala G, Bachmeier C, … Mullan M · J Biol Chem 2014

Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase

Hall J, Aulabaugh A, Rajamohan F, … Qiu X · J Biol Chem 2012

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts

Kroczek C, Lang C, Brachs S, … Mielenz D · J Immunol 2010

Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl

Zou W, Reeve JL, Zhao H, … Teitelbaum SL · J Biol Chem 2009

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