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Cellular model system to dissect the isoform-selectivity of Akt inhibitors

Quambusch L, Depta L, Landel I, … Rauh D · Nat Commun 2021 · Nat Commun 12(1):5297

Akt (Ser/Thr) Ser/Thr kinase Covalent inhibitor kineticsInhibitor discovery & SARSelectivity & kinome profilingMechanism & structural biology PhosphoSens

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More publications on Akt

An ultrasensitive fiveplex activity assay for cellular kinases

Smolko CM, Janes KA · Sci Rep 2019

Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells

Broughton K, Korski K, Echeagaray O, … Sussman MA · Gene Ther 2019

Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor

Dumble M, Crouthamel MC, Zhang SY, … Kumar R · PLoS One 2014

Microfluidic probe for single-cell analysis in adherent tissue culture

Sarkar A, Kolitz S, Lauffenburger DA, Han J · Nat Commun 2014

Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1

Tu Q, Zhang J, Dong LQ, … Chen J · J Biol Chem 2011

Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP, in mouse midbrain, leads to down-regulation of pAkt

Durgadoss L, Nidadavolu P, Valli RK, … Ravindranath V · FASEB J 2011

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