Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K Degraders

Pandurangan T, Zeleke ST, Iermolaieva A, … Rodas M · J Med Chem 2026 · J Med Chem 69(3):2287-2309

CDK12/13 Ser/Thr kinase Inhibitor discovery & SARSelectivity & kinome profiling KinSight services