Comprehensive Kinase & Phosphatase Inhibitor Testing Services for Drug Discovery
Unlock a deeper understanding of inhibitor selectivity, potency, and mechanism of action with AssayQuant's continuous kinetic assay services.
Empower Your Enzyme Inhibitor Programs with Actionable Kinetic Insights
At AssayQuant, we help researchers unlock critical insights with best-in-class assay services designed to drive confidence in decision-making from early discovery through lead optimization.
Our proprietary PhosphoSens® technology enables direct, continuous measurement of kinase and phosphatase activity—providing richer, more reproducible data in less time. Whether you're looking for detailed profiling, custom assay development, or support with challenging targets, our services are tailored to help you move faster, smarter, and further.
Is My Protein Kinase Inhibitor Selective?
Comprehensive Kinase Profiling Services for Drug Discovery and Target Validation
Explore Selectivity & Off-Target Effects
Detailed Kinetic Report for each compound that includes annotated progress curves to call out exploitable mechanisms of actions (MOA) and % inhibition presented in:
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Numerical Format (Tabular), % inhibition for each enzyme
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Graphical Format (Waterfall Plot), % inhibition for each enzyme
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Graphical Format (Waterfall Plot), >70% inhibition
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Visual Format (Kinome Tree), >70% inhibition
How Potent Is My Inhibitor?
Quantitative IC50 Analysis to Support Drug Potency Assessment
Assess Inhibitor and Activator Potency
Accurately determine inhibitor potency (IC50) using real-time kinetic data and physiologically relevant ATP concentrations.
Detailed Kinetic Report for each compound that includes all experimental conditions, annotated progress curves, dose response curves that reports:
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IC50 and Ki (for ATP-competitive inhibitors)
What Is My Compounds Mechanism Of Inhibition?
Advanced Time-Dependent Inhibition (TDI) Services to Measure Residence Time and Kinetics
Unlock Mechanistic Insights
Detailed Kinetic Report for each compound that includes all experimental conditions, annotated progress curves, dose response curves that reports:
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IC50 and Ki (for ATP-competitive inhibitors) for non-time dependent inhibitors.
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Residence time (τ, tau), koff and t1/2 for reversible time dependent inhibitors.
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kinact/KI or kinact and KI for irreversible time dependent inhibitors.
Custom Assay Development Services
We are continually developing new assays to expand kinome coverage to meet the rapidly changing needs of the marketplace. If we don't have your specific kinase or phosphatase assay, we can custom develop a validated assay to meet your needs.
Leverage our expertise to develop and validate a custom PhosphoSens kinase or phosphatase assay tailored to your specific research needs.
Systematic generation and optimization of PhosphoSens Kinase Substrate for monitoring EGFR activity
Technical Research and Development Resources for AssayQuant's Enzyme Activity Assays
The Advantages of Kinome Profiling With a Continuous Assay
Join Earl May, Ph.D., Sr. Director of Discovery Technologies, as he delves into the unique advantages of continuous assays over their endpoint counterparts, reveals hidden insights within raw data, and demonstrates how progress curves can help you identify essential aspects of an inhibitor's mode of action.
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