Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

Wichroski M, Liu SQ, Zasadil LM, … Lees E · Cancer Immunol Res 2025 · Cancer Immunol Res 13(9):1342-1362

DGKα, DGKζ (lipid kinases) Lipid kinase Inhibitor discovery & SARMechanism & structural biology PhosphoSens