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Time-evolved metrics for safety pharmacological assessments of small molecules and biologics

Srinivasan B · Br J Pharmacol 2025 · Br J Pharmacol 182(13):2831-2841

Not specified Ser/Thr kinase Selectivity & kinome profilingReview PhosphoSens

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COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale

Lin H, Yang B, Ding L, … Wang J · Nat Commun 2025

High-throughput mechanistic screening of non-equilibrium inhibitors by a fully automated data analysis pipeline in early drug-discovery

Srinivasan B, Flórez Weidinger JD, Zhai X, … Steigele S · SLAS Discov 2022

A Novel High-Throughput FLIPR Tetra-Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery

Khurana P, McWilliams L, Wingfield J, … Srinivasan B · SLAS Discov 2021

Design and synthesis of fluorescent activity probes for protein phosphatases

Casey GR, Beck JR, Stains CI · Methods Enzymol 2019

Interrogating signaling nodes involved in cellular transformations using kinase activity probes

Stains CI, Tedford NC, Walkup TC, … Imperiali B · Chem Biol 2012

A p38α-selective chemosensor for use in unfractionated cell lysates

Stains CI, Luković E, Imperiali B · ACS Chem Biol 2010

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