Looking For SelectScreen Kinase Profiling Services Alternatives?
Don't just replace SelectScreen, advance your research and development with rich kinetic data and expert analysis.
We Know That Many Of You Are Looking for SelectScreen Kinase Profiling Services Alternatives. We Created This Page To Make Sure You Don't Lose Momentum In Your Research.
Upgrade Your Kinase Profiling with KinSight
Off-target kinase interactions can lead to unintended side effects, reduced efficacy, and clinical trial failures, making kinome profiling a critical tool in drug discovery and development, particularly for small-molecule kinase inhibitors.
With Thermo Fisher Scientific's SelectScreen Kinase Profiling Services being discontinued, researchers need a reliable path forward.
Most biochemical kinase profiling services rely on endpoint assays (like Z’-LYTE™), providing only a single snapshot of enzyme activity. But kinase inhibition is dynamic—why settle for incomplete data?
AssayQuant's KinSight Kinase Panel Screening and Profiling Services deliver everything you need—and more—with a next-generation approach to kinase inhibitor characterization.
Stop Using Outdated Assays—Upgrade to KinSight Today
Move beyond static endpoint data. AssayQuant's KinSight platform delivers continuous kinetic measurements, providing deeper insights into inhibitor selectivity and mechanism of action (MOA) crucial for your drug discovery research. Understand how your compound interacts, not just if it inhibits.
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Detects All Types Of Inhibitors? |
Measures Kinase Activity? |
Direct Phosphorylation Detection |
Real-Time/Continuous Readout |
AQT's KinSight Kinase Profiling |
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SelectScreen Profiling |
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Radiometric Assays |
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Mobility Shift Assays |
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Luminescent Assays |
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Competition Binding |
De-Risk Your Kinase Inhibitor Development with Continuous Activity-Based Biochemical Kinase Selectivity Profiling Services
Advantages of Profiling With a Continuous Assay Format
Most kinome profiling platforms use endpoint assays—single time-point measurements that assume linear reaction kinetics. But this assumption often breaks down due to factors like lag phases, substrate depletion, enzyme instability, or time-dependent inhibition (TDI).
KinSight uses a continuous assay format to overcome these limitations. By monitoring enzyme activity in real time, we calculate actual reaction rates from multiple data points within the true linear range. This delivers higher-confidence selectivity and MOA insights, and enables direct detection of kinetic phenomena like TDI.
Continuous (Kinetic) Activity Monitoring
Capture true inhibition kinetics for higher accuracy and deeper understanding.
Versatile ATP Concentrations
Profile at ATP Km to maximize potency, 1 mM for physiological relevance—or both for maximal MOA insights.
Informative Kinetic Profiling Report
Go beyond % inhibition with annotated kinetic data, revealing exploitable MOA insights.
Industry Leading Kinase Panel
Access 400+ quality-tested wild-type kinases, plus mutant, cascade, and custom panel options.
Correlates With Cell-Based Assays
Our technology is compatible with physiological levels of ATP, Mg2+, Mn2+, and Ca2+ and incorporates relevant activators and cofactors.
Fast Turnaround Time and Expert Guidance
Get comprehensive screening data and expert functional insights in just two weeks.
"AssayQuant's PhosphoSens technology is uniquely suited to advance Vibliome's kinase inhibitor program. PhosphoSens provides a deep understanding of our compounds including specificity, potency, mode-of-inhibition, reversibility, and time-dependent inhibition. This, along with AssayQuant's world-class scientific support and fast turnaround times powered by automation, will make this a highly productive partnership that will accelerate Vibliome's drug development programs."
Kinase Panel Screening Details
Testing Performed:
Selectivity profiling against 400+ wild-type kinase targets run in kinetic mode at a single compound concentration, in duplicate, at 1mM ATP or each targets ATP Km.
Deliverables:
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Numerical Format (Tabular), % inhibition for each enzyme
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Graphical Format (Waterfall Plot), % inhibition for each enzyme
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Graphical Format (Waterfall Plot), >70% inhibition
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Visual Format (Kinome Tree), >70% inhibition
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Also includes annotated progress curves to call out exploitable mechanisms of actions (MOA).
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Fast Turnaround and Expert Guidance:
Screening complete in two weeks so you get results and important functional information about the enzymology of the kinases and nature of the compound quickly!
See the Rich Kinetic Data You'll Receive - Download Sample Report
Interested in exploring our full data report? Download a sample data report complete with known inhibitors and reference compounds. We tested them at variable compound concentrations with ATP concentrations at either Km or 1 mM for each of our 400+ wild-type kinases! Preview the possibilities of kinetic insights into selectivity and mechanism of action (MOA) for your drug discovery research.
We Also Offer Selectivity Profiling For Phosphatase Drug Discovery and Development!
We have the largest number of assays and use sensor phospho-peptide substrates to monitor activity kinetically (in real-time). Learn more by accessing out poster "Sox-based Sensor Phosphopeptides for Continuous, Homogeneous, and Quantitative Monitoring of Protein Phosphatase Activity" below:
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