PhosphoSens enables complex determinations to provide critical understanding of enzyme inhibitor properties to improve drug performance, including:
- Kinome Profiling – 1 or more concentrations & up to 377 Protein Kinase targets (410 assays w/mutants; new assays added continuously).
- IC50 or Ki – 12 pts, BSA or DTT; low or high ATP, protein complexes & crude lysates
- kinact/KI – 24 pts for time-dependent inhibition with covalent compounds
- Residence Time – Uses Jump Dilution method with a range of detection from 30 seconds to 2 days
- Mechanism of Action (MOA) – ATP & peptide or lipid substrates
- EC50 – Assess potency of compounds for target activation