Jack Clark

Measuring ZAP70 Kinase Activity in T-Cell Lysates

ZAP70 is the kinase that turns T-cell receptor (TCR) engagement into downstream signaling. When the...

pERK Is Not ERK Activity: Lessons From a 2026 iScience Study

If you treat cancer cells with an ERK1/2 inhibitor and probe a western blot for phospho-ERK, you...

Why ATP Concentration Changes Your Kinase Inhibitor IC50

Two labs test the same ATP-competitive kinase inhibitor against the same kinase and report IC50...