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Kinase & Phosphatase Assays Reinvented

Get real-time, kinetic data that translates to clinical impact.

Leveraging simpler assays to deliver richer data

Characterizing targets and assessing compound potency, selectivity, and mechanism of action are critical steps in disease research and drug development, especially with the expanding focus on kinase inhibitors.

Developed by MIT scientists, PhosphoSens® technology provides a direct, continuous measure of enzyme activity that captures the complete reaction under physiologically relevant conditions—enabling better decisions regarding target biology and generation of lead candidates to empower faster movement through the drug discovery process. 

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Of the top pharma companies use PhosphoSens

Technology

Single step process

Direct measurement of phosphorylation

Real-time/Continuous measurement

Mimics physiological conditions

Amenable to complex samples

Cost per test

Enzyme-Coupled Assay Systems
Radiometric Assay Systems
Antibody-Based Assay Systems
Mobility Shift Assay Systems  
PhosphoSens *

 

*For Bulk Substrates

Real-time, kinetic assays in our lab or yours

Kinome Profiling Services

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Compound Testing Services

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NEWS

Resources and Data from AssayQuant scientists and partners

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SBIR PHASE II GRANT

Activity-based Sensor Peptides for Direct, High-throughput, and Kinetic Quantitation of Oncogenic Protein Kinases in Unfractionated Cell and Tissue Samples

AssayQuant Technologies was awarded an SBIR Direct Phase II grant on August 15, 2024, to expand PhosphoSens® fluorescence-peptide detection technology for measuring kinase activity in complex samples like cell lysates. This innovation addresses critical gaps in current assay methods, providing a user-friendly, high-impact solution for kinase research and drug development.

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Sox-based Sensor Phosphopeptides for Continuous, Homogeneous, and Quantitative Monitoring of Protein Phosphatase Activity

Protein phosphatases are critical drug targets for cancer therapy development with a need for robust assays that monitor phosphatase enzyme activity. Learn how our assays continuously monitor protein phosphatase activity.

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ON-DEMAND WEBINAR

The Advantages of Kinome Profiling With a Continuous Assay

Join Earl May, Ph.D., Sr. Director of Discovery Technologies, as he delves into the unique advantages of continuous assays over their endpoint counterparts, reveals hidden insights within raw data, and demonstrates how progress curves can help you identify essential aspects of an inhibitor's mode of action.

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POSTER

Development of a Real-Time, Fluorescence Microplate Assay for Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Activity

Epidermal Growth Factor Receptor (EGFR) wild-type and mutant tyrosine kinase activity and the downstream signaling cascades are pivotal in oncogenesis, drug resistance, and tumor recurrence. Learn how our team developed a continuous, real-time, fluorescence-based assay for EGFR tyrosine kinase inhibitors (TKI’s).

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